Injikovatelný hydrogel funkcionalizovaný suspenzí bohatou na trombocyty a mikročásticemi pro urychlení regenerace chrupavky

نویسندگان

  • M. RAMpICHová
  • M. Buzgo
  • B. KřížKová
  • E. pRoSECKá
  • M. pouzAR
  • L. ŠTRAjTová
چکیده

PURPOSE OF THE STUDY Articular cartilage defects arise due to injury or osteochondral disease such as osteonecrosis or osteochondritis dissecans. In adult patients cartilage has minimal ability to repair itself and the lesions develop into degenerative arthritis. Overcoming the low regenerative capacity of the cartilage cells and the Hayflick limit poses a challenge for the therapy of osteochondral defects. Composite scaffolds with appropriate biomechanical properties combined with a suitable blend of proliferation and differentiation factors could be a solution. The aim of this in vitro study was to develop a novel functionalised hydrogel with an integrated drug delivery system stimulating articular cartilage regeneration.

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تاریخ انتشار 2013